Tag Archives: MicroLactin

“You Are What You Eat…”

Chance has gained almost 1000 lbs in over a year and he could still use a few pounds.  He lost wait quickly when he became sick.

Chance also has some factors that put him at a higher rate of weight loss and an increased difficulty maintaining and gaining weight.

  • he is a senior horse
  • a thoroughbred
  • a cribber
  • had an injury which caused him to not run around as much thus losing muscle mass

I slowly upped over the last year, with advisement from a nutritional specialist (her information is at the end of the post along with the name of her book which I found extremely helpful) and my vet, his feed from 3qt twice a day to 11qt twice a day.

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Chance’s current regiment includes:

AM:

  • Two 4qt scoops of Nutrina Safe Choice Senior feed
  • One 3qt scoop of Timothy and Alfalfa pelleted mix
  • I add his supplements
    • 2 scoops of Body Sore (All natural supplement)
    • 2 scoops of Cervical Formula (All natural supplement)
  • I mix it all together with warm water so that it is sloppy (this makes it easier for him to eat at his age and lessens the chance of choking.  Plus, it helps keep him hydrated especially in the winter when he is less inclined to drink as much water).

PM:

  • Two 4qt scoops of Nutrina Safe Choice Senior feed
  • One 3qt scoop of Timothy and Alfalfa pelleted mix
  • I add his supplements
    • 1 Smartpak (Senior Formula, Immune Booster, and Vitamin C)
    • 2 scoops of DuraLactin (All natural anti-inflammatory and pain reducer derived from cow’s milk also called MicroLactin)
    • 2 scoops of Body Sore (All natural supplement)
    • 2 scoops of Cervical Formula (All natural supplement)
  • I add about 5 flakes of hay (Alfalfa mix)
  • Two 3qt scoops of hay stretcher in a separate feed bucket for snacking through the night

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(Chance’s feed before adding water)

I also make sure that he eats his feed from a bucket on the ground.  According to my vet it is the best way for a horse to eat.


Here are Some Nutrition Resources



Horse Feeding Blog

Fox Den Equine

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nutrena-safechoice-senior-horse-feed-cherokee-feed-and-seed-ballground-georgia.jpg

 

 

 

Pump, Pump, Pump It Up!

The vet came out to give Chance and Lucky their fall shots and do some follow up acupuncture on Chance.  The vet said that Chance has increased flexibility especially in his cervical spine and has gained weight and muscle mass!!!!!!

His feeding regiment is as follows:

AM:

  1. 6 quarts of Nutrina Safe Choice Senior Feed
  2. 3 quarts hay stretcher
  3. Alfalfa hay mix (as much as he wants through out the day)

PM:

  1. 6 quarts of Nutrina Safe Choice Senior Feed
  2. 3 quarts hay stretcher
  3. Alfalfa hay mix (as much as he wants through out the day)
  4. 1 Scoops of DuraLactin (Natural anti-inflammatory and pain supplement)
  5. 1 SmartPak (Senior Flex, Immune Boost)

He is out all day when it is cool and all night when it is hot during the day. So he has tons of green grass to eat.  He walks constantly- up and down the hills- and runs around with Lucky.  We also walk ground poles and do stretches and massage every time I come out to the barn.

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We still need to continue upping his weight and muscle mass preferably before winter.  Fingers crossed.

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An All Natural Option?

While doing research on EPM, and ways to prevent a treatment crisis, I came across something called MicroLactin. Below are two of the many studies I found regarding the use of MicroLactin and its use for EPM.

STUDY 1: Journal of Equine Veterinary Science (Impact Factor: 0.89). 09/2005; 25(9):380-382. DOI: 10.1016/j.jevs.2005.08.004
ABSTRACT Fifty-eight horses with inflammation from lameness/foot trauma, muscle and skin trauma, and respiratory, gastrointestinal, and soft tissue toxins were fed MicroLactin (Duralactin Equine, Veterinary Products Laboratories, Phoenix, AZ) as an aid to therapy to inhibit neutrophil participation in the inflammatory response. Based on clinical signs of observed improvement and owner's observations, there was 86% positive effect, 14% no effect. Owner's satisfaction of results was seen by continued use of MicroLactin instead of nonsteroidal anti-inflammatory drugs and steroids in respiratory inflammation and in chronic lameness, myositis, and skin inflammation.
STUDY 2:  Sandhill Equine Center, Southern Pines, NC Journal of Equine Veterinary Science (Impact Factor: 0.89). 06/2009; 29(6):547-550. DOI: 10.1016/j.jevs.2009.05.004
ABSTRACT MicroLactin is a patented milk protein concentrate whose mode of action is proposed to inhibit neutrophil activation in inflammation and to bolster the immune response in musculoskeletal diseases. MicroLactin was empirically used in the treatment of a series of equine clinical cases. MicroLactin was given in two trials to 166 horses in which neutrophils were associated with an inflammatory response. The primary clinical groups having the greatest positive responders to the use of MicroLactin were: respiratory (92%), joint lameness/foot trauma (90%), muscle injury/myositis (92%), equine protozoal myeloencephalitis (EPM) (81%), skin trauma/hypersensitivity (89%), and toxic enteritis (89%). Positive clinical results were seen within 10 to 14 days when MicroLactin was used as a daily treatment either alone or in combination with other anti-inflammatory agents or as an adjunct to the primary treatment.

Every study I read claimed MicroLactin to be a “miracle anti-inflammatory” that aided in cell regrowth. People were raving about this substance that is derived from cow’s milk. The studies dated back to the 80’s and not only suggested that MicroLactin truly was a natural cure all, but that it also had zero side effects or interactions.

I figured that I should give it a try. Again, I looked everywhere and nobody carried it. I looked online and saw that there was a brand called DuraLactin but that I would not be able to actually receive it for about a week. I began looking for supplements that contained the same ingredients as DuraLactin. Sure enough, I was able to find it!

The brand is called Vita-Flex Equinyl.

Vita Flex® Equinyl™ Combo is designed to help ease pain and inflammation associated with training and competition without causing gastrointestinal side effects. This supplement provides joint health support and increases flexibility. It shortens recovery time by reducing the emigration of neutrophils to the site of the inflammation. Contains glucosamine, which helps maintain synovial fluid that lubricates the joints for all day pain associated with daily exercise and activity. 5,000 mg glucosamine, 875 mg chondroitin. 7500 mg MSM. 3.75 lb (60-day supply).

Other EPM Therapies

The below research was found athttp://www.epmhorse.org/Treatment/Other_Therapy.htm

Veterinarians should discuss other drug therapies, in addition to the protozoa killing drugs, to address symptomatic problems that may occur during treatment.  Limiting inflammation of the cerebrospinal column, stimulating the immune system, and anti-oxidants are three things that the owner should be prepared to handle during treatment.  If the veterinarian does not discuss these, ask about them.

Inflammation

An active S. neurona infection in the central nervous system (CNS) will produce both temporary inflammation and permanent nerve damage. The inflammation can get worse when the protozoa start to die during treatment.  This can happen as the treatment drug level builds in the CNS, and is known as a ‘treatment crisis’.  Watch for symptoms to get worse 7 to 14 days after the start of treatment drugs.

Inflammation by itself can cause permanent nerve damage, so treating it is important.  Veterinarians report that horses with higher neurologic deficiencies, and possibly higher levels of protozoa, tend to get treatment crises more often that horses with a Mayhew score of 1.  Some veterinarians will place a horse on anti-inflammatory drugs immediately, to prevent additional damage to the CNS.

Banamine   Many owners already have the non-steroidal anti-inflammatory drug (NSAID) Banamine at the barn.  Even if your horse is a 1 on the Mayhew scale, you may wish to have Banamine on-hand to deal with any worsening of the symptoms. Banamine can cause gastro-intestinal side effects such as ulcers when given in high doses, or longer than five days.  A January 2009 cost was $35 for 5 doses.

MicroLactin   This supplement is gaining recognition as an overall, mild anti-inflammatory.  This non-prescription supplement is a derivative of cows milk, and is known as Duralactin, or the ingredient ComfortX in Equinyl.  MicroLactin does not have side effects, so it can be used over the entire course of treatment.  It is possible to supplement with Banamine during a treatment crisis.  March 2009 price was $50 per month.

Dexamethazone   (Dex) This steroid suppresses the immune system, so it should not be used as an anti-inflammatory for EPM horses except in an extreme neurological case.  Used longer than 5 days, it can cause Laminitis.

DMSO   Dimethyl sulfoxide given intravenously, can be useful when the horse has extreme neurological symptoms.  The veterinarian should administer this drug, it should only be used for short time periods, and it can interact with other drugs.

Immune System

In many regions of the U.S. more than 50% of the horses have been exposed to EPM. Researchers do not know why less than 2% of them get an active infection in the CNS.  Studies on blood of EPM horses indicate a change in the immune system response and cells.  Relapse rates for EPM are high, often with the same symptoms. Some researchers believe that the relapses are latent infections which were never completely killed, and the immune system does not recognize.  Immune system stimulants have been suggested to help the horse fight the infection.

Levasimole   This drug has been used as part of a wormer, and anti-inflammatory.  It is known to increase immune response.  It has not been clinically tested specifically for use with EPM, but is being used for it.

Transfer Factor    This supplement has been around since the 1940’s for human use. The older studies on humans suggest it increases the cell-mediated immune response.  It has not been clinically tested in horses.  The supplement is suggested to increase the cell-mediated immune response (see research below).  It WILL NOT kill the protozoa; it is only an immune booster.  It is made from cow colostrum, eggs, and mushrooms.  At least two companies produce this for equine use, and while the main ingredients are the same, there are differences.  4 Life Research and Nutrition Horizons USA offer this at March 2009 prices of $150 to $200 per month.

Vitamin E

Vitamin E has been shown to relieve inflammation, promote regeneration of nerve cells, and is an anti-oxidant protecting the CNS.  This vitamin is suggested by many veterinarians for supplementation during and after drug treatment for EPM.  It crosses the blood-brain barrier to work in the CNS.  A deficiency in Vitamin E is thought to impair the blood-brain barrier.  It is suggested at therapeutic rates from 5,000 to 10,000 total IU per day.  Add the total Vitamin E content of all supplements and feed to reach the target rate.  Research has shown that natural source vitamin E (D-alpha tocopherol) is absorbed by the body better than manufactured E (DL-alpha-tocopherol).

Recent Research

A 2006 study published in Veterinary Parasitology indicated: “Our results demonstrated that naturally infected horses had significantly (P < 0.05) higher percentages of CD4 T-lymphocytes and neutrophils (PMN) in separated peripheral blood leukocytes than clinically normal horses.  The product MicroLactin has been shown to limit neutrophil activity thereby reducing the inflammation process in the CNS.  The study goes on to say, “Leukocytes from naturally infected EPM horses had significantly lower proliferation responses, as measured by thymidine incorporation, to a non-antigen specific mitogen than did clinically normal horses (P < 0.05).  Cell-mediated immunity is lowered in EPM positive horses.

An ongoing study by Dr. Bello, Journal of Equine Veterinary Science, vol. 28, issue 8 (2008), uses Marquis, MicroLactin, and transfer factor in a protocol.  The initial study involved 28 horses, and 8 more have been studied.  This study was presented at the AVMA conference in 2007, and was published in 2008. The full text article is available below with permission from Dr. Bello.

Continuing research by others indicates controlling inflammation is a large part of the treatment process, and immune system stimulation is critical to avoiding relapses.

January 2012

References:

Veterinary Parasitology 138 (2006) 200–210

J Appl Res Vet Med 2003;1:272-8.

J Eq Vet Sc, vol. 28, issue 8 (2008) 479-482
An Intensive Approach in the Treatment of Clinical Equine Protozoal Myeloencephalitis 

Am J Vet Research, June 2008  Vitamin E

J Eq Vet Sc, vol. 25, issue 9 (2005) 380-382

TheHorse.com articles # 12025, 4829