Tag Archives: Research

Fungal Infections in Horses

www.merckvetmanual.com/horse-owners/disorders-affecting-multiple-body-systems-of-horses/fungal-infections-mycoses-in-horses

Practical Biosecurity Tips to Protect Your Horses – The Horse

Learn equine biosecurity basics for the farm, horse show, and breeding shed to protect your horses from infectious diseases.
— Read on thehorse.com/features/practical-biosecurity-tips-to-protect-your-horse/

10 Common Horse Emergencies & the Skills You Need to Help – Horse Side Vet Guide

#1 Abdominal Pain, Colic Signs Perform Whole Horse Exam™ (WHE) Assess Color of Mucous Membranes Assess Demeanor or Attitude Assess Gut or Intestinal Sounds Assess Manure Assess Capillary Refill Time (CRT) by examining Gums Give Intramuscular (IM) Injection Give Oral Medication Sand Sediment Test…
— Read on horsesidevetguide.com/Common+Horse+Emergencies+and+the+Skills+You+Need+to+Help

EQUINE BOTULISM: An unknown threat

Equine Botulism

Written by Dr. Tom Lenz on behalf of AQHA 

Few horse owners are aware of this disease which is a progressive, paralyzing disease that is 80-100% fatal in affected horses.  Botulism is sometimes referred to as “forage poisoning” in adult horses or “shaker foal syndrome” in foals. The disease is caused by a potent toxin that is produced by the bacterium Clostridium botulinum. This bacterium lives in the soil as well as the intestinal tract of many normal birds and mammals, including the horse. It produces dormant spores that can be found in 18.5% of soil samples tested in the United States. The disease is most prevalent in Kentucky, Ohio, Maryland, Pennsylvania, California, and Tennessee although it can occur in any state in the U.S. Clostridium botulinum produces several different toxins. Type A toxins are often implicated in human infant botulism and are most often found west of the Rocky Mountains. Types B, C, and D toxins are usually involved in cases of equine botulism, with Type B responsible for 85% of horse cases in the U.S.

Horses of any age are susceptible to botulism which may be initiated by one of three ways. In the case of “forage poisoning” the horse ingests toxins that are contaminating feedstuffs such as grain or hay. Feed contamination is most often due to putrefied carcasses of birds or rodents. A Type C botulism outbreak that killed a number of horses in California several years ago was traced back to hay that contained the infected carcass of a rabbit. The bacteria can also enter a horse’s body via contamination of a wound, especially a deep puncture wound. A good example is “Shaker foal syndrome” which is most frequently caused by the bacteria entering the newborn foal’s body through the foal’s moist navel. Something that can be minimized by dipping the foal’s navel in mild iodine solution soon after birth. The third method in which the disease can be initiated is by ingestion of the spores in the soil. The ingested spores activate in the horse’s intestinal tract where they produce potent toxins that are then absorbed. Regardless of the route, once the bacteria have entered the horse’s body they produce toxins that block transmission of nerve impulses to the horse’s muscles. This results in a progressive paralysis of all the major muscle groups and is concluded with paralysis of the diaphragm, which results in death. Once symptoms develop, death may ensue in several hours or take up to a week.

The disease is difficult to diagnose because it resembles several other medical conditions and diseases such as choke, colic, rabies, EPM, and sleeping sickness. Blood samples very rarely contain toxin and necropsy following the death of the horse usually does not provide a conclusive diagnosis. Because the bacteria often occur naturally in the horse’s intestinal tract, isolation of the organism from the sick horse’s intestine is not diagnostic.

Clinical signs of the disease in adult horses suffering from “forage poisoning” initially include loss of facial expression, a sleepy appearance, saliva drooling from the corner of the mouth, loss of tongue control and loss of tail tone. The horse’s appetite is good, but it has a great deal of difficulty in chewing food and appears to be “playing” in their feed and water buckets. As muscular weakness becomes more profound, the horse will experience muscle trembling, generalized sweating and labored breathing. A weakened, shuffling gait may develop and the horse may take stiff, short steps as if walking on eggs. Eventually, the horse goes down and death results due to paralysis of the respiratory muscles. “Shaker foal syndrome” is usually seen in foals one to two months of age but can develop as early as two weeks or as late as 8 months of age. Early signs in foals are similar to those seen in adults in that the foal shows generalized weakness, poor tail tone, and loss of tongue control. The foal will often dribble milk from the mouth and nostrils because of an inability to swallow. Because of muscle weakness, the foal will lie down frequently. When it does rise, it soon develops muscle tremors and collapses. Affected foals may die within 12 hours of exhibiting symptoms or may linger for as long as a week.

Botulism is usually fatal if left untreated. Prior to the advent of antitoxin, the death rate among affected foals was greater than 90%. With the use of antitoxins in conjunction with antibiotics and supportive therapy, the mortality rate can be reduced to less than 25%. Animals unable to swallow should be fed through a nasogastric tube and placed on IV fluids. Once the toxin produced by the bacteria is attached to the nerve ending it cannot be neutralized by the antitoxin. Therefore, early treatment is critical. Even with aggressive therapy, recovery is slow and may require up to two weeks before the affected horse recovers.

Because of the high death rate and the difficulty in diagnosing this disease, prevention through vaccination is critical. A Type-B Toxoid vaccine is available and is quite effective in preventing the disease. In areas where the disease is prevalent, pregnant mares should be initially vaccinated at the 8th, 9th and 10th month of gestation and thereafter at the 10th month of each pregnancy. Yearly vaccination of adults in areas where the disease frequently occurs is also recommended. If unable to vaccinate the mare prior to foaling, limited information suggests that foals vaccinated with the toxoid at 2 weeks, 4 weeks and at 8 weeks of age developed adequate protection, even in the presence of passive maternal antibodies. Currently, no licensed vaccines are available for preventing botulism due to Cl. botulinum types A or C or other subtypes of toxins. Cross-protection between subtypes does not occur.

As in all horse health issues, your local veterinarian is your best source of information.

ABOUT THE AUTHOR: Thomas R. Lenz, DVM, M.S., Diplomate of the American College of Theriogenologists, is a trustee of the American Horse Council, past chairman of AQHA’s research committee and past president of the American Association of Equine Practitioners. This article is provided courtesy of AAEP Alliance Partner, AQHA.

 
Reviewed and updated by original author in 2016.

Spotting Lameness: The Game Plan

Spotting Lameness: The Game Plan
— Read on horsenetwork.com/2018/10/spotting-lameness-game-plan/

When it rains…

ker.com/equinews/white-line-disease-requires-early-diagnosis-and-aggressive-treatment/

Dealing With Equine Colic: Here are 33 Do’s and Don’ts – The Horse

What should you do (or not do) if your horse shows signs of colic? And how do you prevent colic in the first place? Find out from our veterinary experts.
— Read on thehorse.com/features/dealing-with-equine-colic/

Gut Check: A New View from the Inside

Researchers are testing an endoscopic camera, contained in a small capsule and placed directly into the horse’s stomach, to gather imagery of the equine intestinal tract. The capsule sends images to an external recorder, held in place by a harness.

Researchers are testing an endoscopic camera, contained in a small capsule and placed directly into the horse’s stomach, to gather imagery of the equine intestinal tract. The capsule sends images to an external recorder, held in place by a harness.

Courtesy, Western College of Veterinary Medicine

Traditionally, veterinarians’ and researchers’ view of the equine intestinal tract has been limited. Endoscopy (inserting through the horse’s mouth a small camera attached to a flexible cable to view his insides) allows them to see only as far as the stomach. While ultrasound can sometimes provide a bigger picture, the technology can’t see through gas—and the horse’s hindgut (colon) is a highly gassy environment.

These limitations make it hard to diagnose certain internal issues and also present research challenges. But the view is now expanding, thanks to a “camera pill” being tested by a team at the University of Saskatchewan, led by Julia Montgomery, DVM, PhD, DACVIM. Dr. Montgomery worked with a multi-disciplinary group, including equine surgeon Joe Bracamonte, DVM, DVSc, DACVS, DECVS, electrical and computer engineer Khan Wahid, PhD, PEng, SMIEEE, a specialist in health informatics and imaging; veterinary undergraduate student Louisa Belgrave and engineering graduate student Shahed Khan Mohammed.

In human medicine, so-called camera pills are an accepted technology for gathering imagery of the intestinal tract. The device is basically an endoscopic camera inside a small capsule (about the size and shape of a vitamin pill). The capsule, which is clear on one end, also contains a light source and an antenna to send images to an external recording device.

The team thought: Why not try it for veterinary medicine?

They conducted a one-horse trial using off-the-shelf capsule endoscopy technology. They applied sensors to shaved patches on the horse’s abdomen, and used a harness to hold the recorder. They employed a stomach tube to send the capsule directly to the horse’s stomach, where it began a roughly eight-hour journey through the small intestine.

The results are promising. The camera was able to capture nearly continuous footage of the intestinal tract with just a few gaps where the sensors apparently lost contact with the camera. For veterinarians, this could become a powerful diagnostic aid for troubles such as inflammatory bowel disease and cancer. It could provide insight on how well internal surgical sites are healing. It may also help researchers understand normal small-intestine function and let them see the effect of drugs on the equine bowel.

The team did identify some challenges in using a technology designed for humans. They realized that a revamp of the sensor array could help accommodate the horse’s larger size and help pinpoint the exact location of the camera at any given time. That larger size also could allow for a larger capsule, which in turn could carry more equipment—such as a double camera to ensure forward-facing footage even if the capsule flips.

With this successful trial run, the team plans additional testing on different horses. Ultimately, they hope to use the information they gather to seek funding for development of an equine-specific camera pill.

“From the engineering side, we can now look at good data,” Dr. Wahid explained. “Once we know more about the requirements, we can make it really customizable, a pill specific to the horse.”

This article was originally published in Practical Horseman’s October 2016 issue.