Tag Archives: antibiotics

Immune Booster Leads to Infection?

For the past 6 weeks, my horse has been receiving Ozonetherapy to aid in his chronic back leg related issues- dermatitis (“scratches”), previous DDFT tendon laceration, a history of Lymphingitis, and the residual scar tissue from his DDFT injury.  Due to his age (27), he lacks proper circulation in his hind end which does not help him fight his pastern dermatitis.  


According to the American Academy of Ozonetherapy, Ozonetherapy is described as;

“Ozonotherapy is the use of medical grade ozone, a highly reactive form of pure oxygen, to create a curative response in the body. The body has the potential to renew and regenerate itself. When it becomes sick it is because this potential has been blocked. The reactive properties of ozone stimulate the body to remove many of these impediments thus allowing the body to do what it does best – heal itself.”

“Ozonotherapy has been and continues to be used in European clinics and hospitals for over fifty years. It was even used here in the United States in a limited capacity in the early part of the 20th century. There are professional medical ozonotherapy societies in over ten countries worldwide. Recently, the International Scientific Committee on Ozonotherapy (ISCO3) was formed to help establish standardized scientific principles for ozonotherapy. The president of the AAO, Frank Shallenberger, MD is a founding member of the ISCO3.”

“Ozonotherapy was introduced into the United States in the early 80’s, and has been increasingly used in recent decades. It has been found useful in various diseases;

  • It activates the immune system in infectious diseases.
  • It improves the cellular utilization of oxygen that reduces ischemia in cardiovascular diseases, and in many of the infirmities of aging.
  • It causes the release of growth factors that stimulate damaged joints and degenerative discs to regenerate.
  • It can dramatically reduce or even eliminate many cases of chronic pain through its action on pain receptors.
  • Published papers have demonstrated its healing effects on interstitial cystitis, chronic hepatitis, herpes infections, dental infections, diabetes, and macular degeneration.”

 

After doing research and speaking to one of my good friends, we determined that Chance’s flare up of Lymphingitis, after almost 3 years of not a single issue, could possibly be caused by his immune system’s response to Ozonetherapy.  Let me explain.

Chance suffers from persistent Pastern dermatitis (“scratches”) since I purchased him in 2000.  I have tried everything- antibiotics, every cream and ointment and spray for scratches, diaper rash ointment, iodine and vaseline mix, Swat, laser treatments, scrubs and shampoos, shaving the area, wrapping the area, light therapy…you name it, I have tried it.  So, when we began Ozonetherapy to help break down the left over scar tissue from his old DDFT injury, I noticed that his scratches were drying up and falling off.  We continued administering the Ozonetherapy once a week for about 6 weeks.  The improvement was dramatic!  

However, one day Chance woke up with severe swelling in his left hind leg and obviously, he had difficulty walking.  He received Prevacox and was stall bound for 24 hours.  The vet was called and she arranged to come out the following day.  The next morning, Chance’s left leg was still huge and he was having trouble putting weight on it.  I did the typical leg treatments- icing, wrapping.  The swelling remained.  I tried to get him out of his stall to cold hose his leg and give him a bath but he would not budge.  He was sweaty and breathing heavily and intermittently shivering.  So, I gave him an alcohol and water sponge bath and continued to ice his back legs.   I sat with him for 4 hours waiting for the vet to arrive.  He had a fever and wasn’t interested in eating and his gut sounds were not as audible.  He was drinking, going to the bathroom, and engaging with me.  I debated giving him Banamine but did not want it to mask anything when the vet did arrive.  

The vet arrived, gave him a shot of Banamine and an antihistamine and confirmed that Chance had a fever of 102 degrees and had Lymphingitis.  There was no visible abrasion, puncture, or lump… I asked the vet to do x-rays to ensure that he did not have a break in his leg.  The x-rays confirmed that there was no break.  The vet suggested a regiment of antibiotics, steroids (I really am against using steroids due to the short-term and long-term side effects but in this case, I would try anything to make sure he was comfortable) , prevacox, and a antacid to protect Chance from stomach related issues from the medications.  It was also advised to continue to cold hose or ice and keep his legs wrapped and Chance stall bound.  

The following day, Chance’s legs were still swollen but his fever had broken.  The vet called to say that the CBC had come back and that his WBC was about 14,00o. She suggested that we stop the steroids and do the antibiotic 2x a day and add in Banamine. I asked her if she could order Baytril (a strong antibiotic that Chance has responded well to in the past) just in case.  And that is what we did.  

Being as Chance had such a strong reaction to whatever it was, I did some thinking, discussing, and researching…first and foremost, why did Chance have such an extreme flare up of Lymphingitis when he was the healthiest he has ever been?  And especially since he had not had a flare up in 3+ years…plus, his scratches were getting better not worse.  The Ozonetherapy boosted his immune system and should provide him with a stronger defense against bacteria, virus’, etc.  So why exactly was he having a flare up?  And that is when it hit me!

In the past when Chance began his regiment of Transfer Factor (an all natural immune booster), he broke out in hives.  The vet had come out and she felt it was due to the Transfer Factor causing his immune system to become “too strong” and so it began fighting without there being anything to fight, thus the hives.  My theory- Chance started the Ozonetherapy and his body began to fight off the scratches by boosting his immune system.  As the treatments continued, his immune system began to attack the scratches tenfold.  This resulted in his Lymphatic system to respond, his WBC to increase, and his body temperature to spike.  Makes sense…but what can I do to ensure this is not going to happen again?  

My friend suggested attacking the antibiotic resistant bacteria by out smarting them…okay, that seems simple enough…we researched the optimal enviroments for the 3 types of bacteria present where Chance’s scratches are (shown in the results of a past skin scape test).  The bacteria – E. Coli, pseudomonas aeruginosa and providencia Rettgeri. The literature stated that PA was commonly found in individuals with diabetes…diabetes…SUGAR!  How much sugar was in Chance’s feed?  I looked and Nutrina Safe Choice Senior feed is low in sugar…so that is not it.  What else can we find out?  The optimal temperature for all three bacteria is around 37 degrees celsius (or 98.6 degrees fahrenheit), with a pH of 7.0, and a wet environment. Okay, so, a pH of 7.0 is a neutral.  Which means if the external enviroment (the hind legs)pH is thrown off, either to an acidic or alkaline pH, the bacteria will not have the optimal enviroment to continue growing and multiplying.  How can I change the pH?  

Vinegar!  An antimicrobial and a 5% acetic acid! And…vinegar is shown to help kill mycobacteria such as drug-resistant tuberculosis and an effective way to clean produce; it is considered the fastest, safest, and more effective than the use of antibacterial soap.  Legend even says that in France during the Black Plague, four thieves were able to rob the homes of those sick with the plague and not become infected.  They were said to have purchased a potion made of garlic soaked in vinegar which protected them.  Variants of the recipe, now called “Four Thieves Vinegar” has continued to be passed down and used for hundreds of years (Hunter, R., 1894).

I went to the store, purchased distilled vinegar and a spray bottle and headed to the farm.  I cleaned his scratches and sprayed the infected areas with vinegar.  I am excited to see whether our hypothesis is correct or not…I will keep you posted!

 


References & Information


Effect of pH on Drug Resistent Bacteriaijs-43-1-174

NIH: Drug Resistant Bacteria

Vinegar

Lymphatic Conditions

Horses Side Vet Guide

What does my horse’s CBC mean?

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Nutrena SC Senior feed ingredience
The American Academy of Ozonetherapy

Hunter, Robert (1894). The Encyclopaedic Dictionary. Toronto: T.J. Ford. ISBN 0-665-85186-3.

 

If You Experience Worsening Depression…

Chance began another round of Excede to get his scratches under control- it is a never ending battle.  A while back, I had a skin scrape of Chance’s scratches due to their chronic nature.  The scrape results showed a number of bacteria, all commonly seen with this type of infection, that were resistant to most antibiotics.  Thus why we decided to try Excede.

Administering Excede is pretty straight forward- 1 shot IM every 4 days for about a month.  Easy enough….or so I thought.  The first shot was administered by the vet when I was not present.  The second shot the vet also administered while I was there.  Thirty minutes after the shot was given to Chance I noticed he seemed off but not in his “normal” post-acupuncture relaxed state. He suddenly became lethargic, he wouldn’t eat his dinner, and the gut noises became almost nonexistent. I commented to the vet my concerns and she came over and reexamined him.  Sure enough something was wrong.  She proceeded to administer 10cc of Banamine (just in case it was colic) and told me to walk him around outside for about 20-30 minutes.  Then see if he would eat 2 cups of feed only.  We walked and Chance began to act like his normal happy go lucky self.  Once inside he started to eat!

Part of me felt that his reaction was a fluke.  However, the third dose proved me wrong.  Four days later, Chance received his shot and went outside to enjoy the first beautiful, warm day.  I sat in the field watching him.  He was sluggish, lethargic, stiff..he looked 10 years older and barely moved from one spot under a tree.  He wasn’t eating grass nor did he run around and play- he didn’t even run up to me like he normally would. I decided to bring him inside and give him a warm bath since it was in the high 70’s.  He was non responsive to his bath- no playing with the hose or even accepting peppermints.  I placed a cooler on him to ensure he stayed warm until he was out in the sunshine.  I figured after a bath he would perk up- again, I was wrong.  At dinner time I went to bring him in and typically I will open up the gait and he will canter into his stall- he slowly walked instead. He wouldn’t eat his feed (he normally whinnies and makes a fuss until he gets his feed and devours it) or his hay…I stayed and watched him for a while and he just slept.  I spoke to John, the guy who helps me with Chance and Lucky, and he confirmed that Chance hadn’t been finishing his feed and wasn’t running when he brought him in for dinner.

My concerns grew and I decided to do some research on Excede. That strange thing is I usually do extensive research before changing or administering anything with my animals.  But, for some reason I did not do so this time and I wish I had.

According to a number of reputable websites, Excede can cause significant and dangerous side-effects such as; diarrhea, severe acid reflux, blood coming from mouth, loss of appetite, lethargy, muscle and gait stiffness, and more.

The most troubling of everything that I read wasn’t what was posted on the Pfizer (the manufacturer) website but from the countless statements given by horse owners and the studies done by outside companies.

According to drugs.com, “in the PK study, several horses developed clinical signs consistent with foot pain (stiff in the front limbs when turned in tight circles, and increased pulses and heat to the front feet). One horse in the NAXCEL group and one horse in the 6.0 mg/lb (2X) EXCEDE group were euthanized due to laminitis. Clinical signs of foot pain (stiff front limbs and increased heat and pulses in feet) affected more horses, for a longer period of time, in all EXCEDE-treated groups as compared to the NAXCEL-treated group. The study housing (multi-horse pens on concrete slabs) and diet (free choice alfalfa/grass mix and once a day pellets) may have contributed to the development of foot pain. The prevalence and severity of injection site reactions in EXCEDE-treated horses may also have contributed to the development of a stiff gait. A causal relationship between ceftiofur and foot pain could not be definitively determined.”

The research has revealed that Excede should be used with caution and the horse receiving the medication must be monitored. Make sure to weigh the benefits and risks before starting Excede.  This drug can be lifesaving for many horses but for others, it can be life-threatening.


Excede Resources


Straight from the Horse’s Mouth: Antibiotics, Antifungals, Antivirals

Excede Study

Equine Product Catalog: In depth understanding of equine medications

FINALNewMexicoEIBPetitionExhibits2908-1407_pdf

 

And They’re Back….Scratches, Scratches EVERYWHERE!

Over the last couple weeks the rain has been unrelenting.  And with rain comes scratches (Pastern Dermatitis).  In a previous entry I spoke about an amazing treatment for scratches that actually worked…however, when it rains like it has recently, once again the scratches got out of control.

A handful of months ago I got a skin scrape on Chance’s hind legs to determine the bacteria that was causing the scratches.  Sure enough there were three types of bacteria growing which was why I was having so much difficulty getting them under control.

Below are the results:

Version 2

As you can see above, the bacteria shows resistance or no interpretation to all but 7 antibiotics.  I spoke to my vet and she suggested beginning with Gentamicin and go from there if he does not respond to the medication.  Chance has been receiving an injection of 30 mls of Gentamicin in his muscle once a day for about a week now.  He obviously does not enjoy this, nor do I for that matter, but his scratches are showing improvements!  He is also on the topical cream, Silver Sulfadiazine, once a day.

Fingers crossed that I will get ahead of the scratches and they will go away forever!