For the past 6 weeks, my horse has been receiving Ozonetherapy to aid in his chronic back leg related issues- dermatitis (“scratches”), previous DDFT tendon laceration, a history of Lymphingitis, and the residual scar tissue from his DDFT injury. Due to his age (27), he lacks proper circulation in his hind end which does not help him fight his pastern dermatitis.
According to the American Academy of Ozonetherapy, Ozonetherapy is described as;
“Ozonotherapy is the use of medical grade ozone, a highly reactive form of pure oxygen, to create a curative response in the body. The body has the potential to renew and regenerate itself. When it becomes sick it is because this potential has been blocked. The reactive properties of ozone stimulate the body to remove many of these impediments thus allowing the body to do what it does best – heal itself.”
“Ozonotherapy has been and continues to be used in European clinics and hospitals for over fifty years. It was even used here in the United States in a limited capacity in the early part of the 20th century. There are professional medical ozonotherapy societies in over ten countries worldwide. Recently, the International Scientific Committee on Ozonotherapy (ISCO3) was formed to help establish standardized scientific principles for ozonotherapy. The president of the AAO, Frank Shallenberger, MD is a founding member of the ISCO3.”
“Ozonotherapy was introduced into the United States in the early 80’s, and has been increasingly used in recent decades. It has been found useful in various diseases;
- It activates the immune system in infectious diseases.
- It improves the cellular utilization of oxygen that reduces ischemia in cardiovascular diseases, and in many of the infirmities of aging.
- It causes the release of growth factors that stimulate damaged joints and degenerative discs to regenerate.
- It can dramatically reduce or even eliminate many cases of chronic pain through its action on pain receptors.
- Published papers have demonstrated its healing effects on interstitial cystitis, chronic hepatitis, herpes infections, dental infections, diabetes, and macular degeneration.”
After doing research and speaking to one of my good friends, we determined that Chance’s flare up of Lymphingitis, after almost 3 years of not a single issue, could possibly be caused by his immune system’s response to Ozonetherapy. Let me explain.
Chance suffers from persistent Pastern dermatitis (“scratches”) since I purchased him in 2000. I have tried everything- antibiotics, every cream and ointment and spray for scratches, diaper rash ointment, iodine and vaseline mix, Swat, laser treatments, scrubs and shampoos, shaving the area, wrapping the area, light therapy…you name it, I have tried it. So, when we began Ozonetherapy to help break down the left over scar tissue from his old DDFT injury, I noticed that his scratches were drying up and falling off. We continued administering the Ozonetherapy once a week for about 6 weeks. The improvement was dramatic!
However, one day Chance woke up with severe swelling in his left hind leg and obviously, he had difficulty walking. He received Prevacox and was stall bound for 24 hours. The vet was called and she arranged to come out the following day. The next morning, Chance’s left leg was still huge and he was having trouble putting weight on it. I did the typical leg treatments- icing, wrapping. The swelling remained. I tried to get him out of his stall to cold hose his leg and give him a bath but he would not budge. He was sweaty and breathing heavily and intermittently shivering. So, I gave him an alcohol and water sponge bath and continued to ice his back legs. I sat with him for 4 hours waiting for the vet to arrive. He had a fever and wasn’t interested in eating and his gut sounds were not as audible. He was drinking, going to the bathroom, and engaging with me. I debated giving him Banamine but did not want it to mask anything when the vet did arrive.
The vet arrived, gave him a shot of Banamine and an antihistamine and confirmed that Chance had a fever of 102 degrees and had Lymphingitis. There was no visible abrasion, puncture, or lump… I asked the vet to do x-rays to ensure that he did not have a break in his leg. The x-rays confirmed that there was no break. The vet suggested a regiment of antibiotics, steroids (I really am against using steroids due to the short-term and long-term side effects but in this case, I would try anything to make sure he was comfortable) , prevacox, and a antacid to protect Chance from stomach related issues from the medications. It was also advised to continue to cold hose or ice and keep his legs wrapped and Chance stall bound.
The following day, Chance’s legs were still swollen but his fever had broken. The vet called to say that the CBC had come back and that his WBC was about 14,00o. She suggested that we stop the steroids and do the antibiotic 2x a day and add in Banamine. I asked her if she could order Baytril (a strong antibiotic that Chance has responded well to in the past) just in case. And that is what we did.
Being as Chance had such a strong reaction to whatever it was, I did some thinking, discussing, and researching…first and foremost, why did Chance have such an extreme flare up of Lymphingitis when he was the healthiest he has ever been? And especially since he had not had a flare up in 3+ years…plus, his scratches were getting better not worse. The Ozonetherapy boosted his immune system and should provide him with a stronger defense against bacteria, virus’, etc. So why exactly was he having a flare up? And that is when it hit me!
In the past when Chance began his regiment of Transfer Factor (an all natural immune booster), he broke out in hives. The vet had come out and she felt it was due to the Transfer Factor causing his immune system to become “too strong” and so it began fighting without there being anything to fight, thus the hives. My theory- Chance started the Ozonetherapy and his body began to fight off the scratches by boosting his immune system. As the treatments continued, his immune system began to attack the scratches tenfold. This resulted in his Lymphatic system to respond, his WBC to increase, and his body temperature to spike. Makes sense…but what can I do to ensure this is not going to happen again?
My friend suggested attacking the antibiotic resistant bacteria by out smarting them…okay, that seems simple enough…we researched the optimal enviroments for the 3 types of bacteria present where Chance’s scratches are (shown in the results of a past skin scape test). The bacteria – E. Coli, pseudomonas aeruginosa and providencia Rettgeri. The literature stated that PA was commonly found in individuals with diabetes…diabetes…SUGAR! How much sugar was in Chance’s feed? I looked and Nutrina Safe Choice Senior feed is low in sugar…so that is not it. What else can we find out? The optimal temperature for all three bacteria is around 37 degrees celsius (or 98.6 degrees fahrenheit), with a pH of 7.0, and a wet environment. Okay, so, a pH of 7.0 is a neutral. Which means if the external enviroment (the hind legs)pH is thrown off, either to an acidic or alkaline pH, the bacteria will not have the optimal enviroment to continue growing and multiplying. How can I change the pH?
Vinegar! An antimicrobial and a 5% acetic acid! And…vinegar is shown to help kill mycobacteria such as drug-resistant tuberculosis and an effective way to clean produce; it is considered the fastest, safest, and more effective than the use of antibacterial soap. Legend even says that in France during the Black Plague, four thieves were able to rob the homes of those sick with the plague and not become infected. They were said to have purchased a potion made of garlic soaked in vinegar which protected them. Variants of the recipe, now called “Four Thieves Vinegar” has continued to be passed down and used for hundreds of years (Hunter, R., 1894).
I went to the store, purchased distilled vinegar and a spray bottle and headed to the farm. I cleaned his scratches and sprayed the infected areas with vinegar. I am excited to see whether our hypothesis is correct or not…I will keep you posted!
References & Information
Hunter, Robert (1894). The Encyclopaedic Dictionary. Toronto: T.J. Ford. ISBN 0-665-85186-3.
Today Chance had swelling of his back right fetlock. He had a fever around 104 and didn’t eat his feed. His eyes were dull and he was lethargic. He wasn’t limping but was walking slower than normal (he usually runs to the paddock or back to the barn). I decided, due to the Lymphingitis flare up on his back right leg, I would give him a shot of 5 mls (or 5 cc) of Banamine and wrap his leg. Once the medication set in, I would bring him in to give him a bath (it was 80 degrees today). So, that is what I did. By the time he was back at the barn he was covered in sweat. I cold hosed him and drenched the wrap in cool water and let him roam around the barn.
Thankfully, the vet was able to meet me at her veterinary practice so that I could pick up Baytril and more Banamine. Since Chance just had Lyme Disease (and had finished his medication less than a week ago), we are not 100% if this is a Lyme reaction or something else. The plan is to administer 25 cc of Baytril either orally, in his feed, or via IV for 6 days and Banamine 10 mls (or a 1000 lbs) twice a day for 3 days. The vet suggested that I do 5 cc of Banamine if his fever remains between 101-103 degrees and 10 cc if his fever is 103 degrees or above. During this time I will begin Prevacox- one 1/4 of a tablet once a day. After 3 days, I will discontinue the Banamine and continue the Prevacox. If his fevers are not down in two days, I will continue the Baytril but start the doxycycline as it maybe a Lyme disease symptom.
While researching Lyme Disease, I found that many people do two+ months of doxycycline instead of 30 days to ensure the disease has been erraticated completely. However, since Chance had shown such improvement after 30 days, I decided to not do another month. Maybe I should have…
However, Chance had similar symptoms when we found a small laceration in the DDFT tendon of his back left hind- swelling, Lymphingitis, fever, lethargy, no appetite, etc. If he does have an issue with his tendon I will most likely do another round of Stem Cell treatments which proved to be helpful last time. Thankfully I stored his stem cells in a Stem Cell Bank (via Vet-Stem) and can easily have them shipped.
True North Equine Vets www.truenorthequinevets.com 540-364-9111
Genesis Farriers: Dave Giza www.genesisfarriers.com 571-921-5822
Ken Pankow www.horsedentistvirginia.com 540-675-3815
Full Circle Equine www.fullcircleequine.com 540-937-1754
Farriers Depot: (Farrier related supplies) www.farriersdepot.com 352-840-0106
StemVet (Stem cell acquisition and storage) www.vet-stem.com
SmartPak Equine Supplements www.smartpakequine.com
OZONE THERAPY – HISTORY, PHYSIOLOGY, INDICATIONS, RESULTS
Judith M. Shoemaker, DVM 305 Nottingham Road Nottingham, PA 19362
717-529-0526 Fax 717-529-0776
Ozone therapy has been utilized and heavily studied for more than a century. Its effects are proven, consistent, safe and without side effects. Why is it not more universal in its use? Many of you have come with some trepidation about infusing a gas into a vessel because you are concerned about emboli, or have some dreadful fear about ozone’s toxicity since we frequently hear about the unhealthy ozone levels in the atmosphere. These fears do not apply to properly administered medical ozone, and the potential benefits of ozone therapy are profound and without associated detrimental effects.
Oxygen, in its several forms, cycles through the atmosphere and life processes just as water does. Ozone is produced in the upper atmosphere when UV light strikes the oxygen rising from plants, plankton, and algae in our forests and seas. It then falls back through the atmosphere, as it is heavier than air, combining with pollutants and water, cleaning the air and forming peroxides that benefit plants. Ultraviolet light breaking down pollutants and nitrous oxides also can produce ozone at the ground level, which is the eye and lung irritant in smog.
Medical ozone, used to disinfect and treat disease, has been around for over 150 years. Used to treat infections, wounds, and multiple diseases, ozone’s effectiveness has been well documented. Ozone has been used to disinfect drinking water since before the turn of the last century. A text on medical ozone therapy was published by Dr. Charles J. Kenworth in 1885! The best technology for producing ozone gas was designed and built by Nikola Tesla in the 1920’s. Heads of leading medical institutions in the U.S. contributed to a 1929 book “Ozone and Its Therapeutic Actions” describing the treatment of 114 diseases using ozone.
In 1933, the AMA began its systematic suppression of all modalities of treatment that did not complement its liaison with the emerging pharmacologic and diagnostic industries. Ozone therapy, along with many other useful therapies, were methodically eliminated from the educational process and exposure to the public in the U.S.
Less suppression has occurred in Europe and other countries, especially in Russia. Today in Germany, and other countries, ozone therapy is commonplace. Over 7000 doctors in Germany use it daily. In fact, in Germany, ozone generators are in ambulances for treatment of stroke victims. The incidence of permanent paralysis in these patients is much less than that in similar patients where ozone is not used.
Ozone generators are relatively simple and inexpensive. The equipment used to handle ozone is readily available but needs to be relatively non-reactive. Glass, Teflon, Kynar, silicon, and gold are completely non-reactive. Equipment made of other substances can contaminate the ozone or just deteriorate rapidly using up the ozone and becoming nonfunctional.
Generators use several technologies to produce ozone
- UV lamp – makes small amounts of ozone and is unreliable in making accurate concentrations. They burn out easily.
- Corona discharge – dual dielectric sealed systems produce ozone but also lots of heat which is both destructive to ozone and to the machine.
- Cold plasma generators – which produce ozone using low level current passed in 2 tubes of a noble gas between which an electrostatic plasma field forms that ionizes the oxygen.Ozone concentration is measured in u/ml or gms/L of oxygen, 5% or 70 u/ml is usually the maximum concentration used in clinical medical applications. High concentrations will damage red cells and inhibit growth of healthy cells.Dosage and frequency protocols vary widely. Initial high dose treatments may “jumpstart” the immune system followed by lower doses. Those who are fearful have been “starting slow and going low” with dosage and still have good results. Concentration must be carefully controlled with accurate flow rates, requiring pediatric regulators for the needed slow flow rates to produce high concentrations. Therefore, home made machines and lesser quality nonmedical devices are not appropriate.
Ozone poteniates free radical scavenging substances and systems in the body, inducing the production of superoxide dismutase, catalase, and glutathione peroxidase. If ozone administration causes any respiratory irritation from out-gassing through the lungs, a bolus dose of 1 to 5 grams of vitamin C can be given and will eliminate any coughing instantly.
Oxygen/ozone mixtures cannot cause emboli when injected at reasonable rates as they dissolve and diffuse very quickly in body fluids, unlike air (predominantly nitrogen) which is what forms emboli and causes the bends or decompression disease.
The physiologic actions of ozone are many, the simplest of which is to provide sufficient oxygen to allow complete oxidation of sugars and other fuels to produce sufficient and efficient energy and to “burn clean” to CO2, water, and inert end products. If not enough oxygen is available, then incomplete oxidation occurs, producing carbon monoxide, lactic acid, and partially oxidized toxins that inhibit further oxygen metabolism and “clog the system”, tying up hemoglobin, water, and the mechanisms for function and elimination.
Administration can be through any route with modifications:
- Direct IV infusion – Ozone slowly administered into a major vessel.
- Major auto-hemotherapy – Anticoagulated blood is mixed with ozone and is infused into a vessel.
- Rectal/vaginal insufflation – Humidified ozone is administered by catheter.
- Minor autohemotherapy – Blood mixed with ozone is injected intramuscularly.
- Limb or body bagging – Body or parts are bathed in humidified ozone.
- Ozonated water – Dissolves easily in water to be used topically or consumed.
- Ozone in Saline or LRS – Can be used topically or given IV or SQ.
- Intra-articular administration – For joint healing and prolotherapy.
- Prolo/Sclerotherapy – Very good, less painful than other agents.
- Acupuncture – With ozone, more effective than B12.
- Ozonated olive oil – Ozone is bubbled through oil until the oil is thickened. This will produce ozonides that are not irritating and thus is applied topically even to eyes.
- Inhalation – Ozone that has been bubbled through olive oil and humidified will not irritate respiratory epithelium.
- Subconjunctival injection – For ulcers and keratitis sicca.
- Gingival and tooth apex injection – Can eliminate infection.
- Urinary bladder insufflation – For chronic inflammation.
- Disc protrusions – Prolotherapy, which can be injected at interspinous space and around facets, stabilize joints and accelerate healing.
- Auricular – Can be direct, humidified, or bagged with a homemade device made from IV bags and tubing (á la Margo Roman).As an anticancer, antiviral, antibacterial, and ant fungal agent, ozone is unsurpassed, especially since there are no appreciable side effects.Oxygen deficit is key to the development and progression of all disease processes. Dr. Otto Warburg’s work, confirmed by others, shows that this deficit and subsequent toxin buildup is the fundamental cause of all degenerative disease, especially cancers.
Antioxidants help the body to protect itself from excessive oxidative damage caused by multiple free radicals, many of which are inactivated by ozone. The support of free radical scavenging systems is important but only oxygen can improve the deficit that makes cells vulnerable to oxidative damage in the first place. Long-term ozone therapy can be augmented by supplementation with antioxidants, but normally they should not be administered within 4 to 12 hours of ozone therapies.
Ozone produces the same effects as exercise, which produces significantly more free radical oxygen than can be administered in any ozone treatment. Ozone equals ”exercise in a syringe” without doing joint damage.
Ozone potentiates more complete oxidation, helps to maintain more normal body temperature and increases the effects of most hormones, vitamins, herbs, homeopathics, and drugs. Concurrent ozone administration reduces the amount of chemotherapeutic drugs needed to achieve effect by 1⁄4 to 3⁄4. It complements chelation therapies and frequently improves the affect and sense of well being in patients.
Continued therapy will allow Herring’s Law to manifest “Healing from inside to outside, top to bottom, front to rear, and in reverse chronological order of the insults to the body.” Healing crises, however, may occur. Ozone therapy facilitates the rapid resolution of these crises.
2005 Judith M. Shoemaker, DVM
Chance began another round of Excede to get his scratches under control- it is a never ending battle. A while back, I had a skin scrape of Chance’s scratches due to their chronic nature. The scrape results showed a number of bacteria, all commonly seen with this type of infection, that were resistant to most antibiotics. Thus why we decided to try Excede.
Administering Excede is pretty straight forward- 1 shot IM every 4 days for about a month. Easy enough….or so I thought. The first shot was administered by the vet when I was not present. The second shot the vet also administered while I was there. Thirty minutes after the shot was given to Chance I noticed he seemed off but not in his “normal” post-acupuncture relaxed state. He suddenly became lethargic, he wouldn’t eat his dinner, and the gut noises became almost nonexistent. I commented to the vet my concerns and she came over and reexamined him. Sure enough something was wrong. She proceeded to administer 10cc of Banamine (just in case it was colic) and told me to walk him around outside for about 20-30 minutes. Then see if he would eat 2 cups of feed only. We walked and Chance began to act like his normal happy go lucky self. Once inside he started to eat!
Part of me felt that his reaction was a fluke. However, the third dose proved me wrong. Four days later, Chance received his shot and went outside to enjoy the first beautiful, warm day. I sat in the field watching him. He was sluggish, lethargic, stiff..he looked 10 years older and barely moved from one spot under a tree. He wasn’t eating grass nor did he run around and play- he didn’t even run up to me like he normally would. I decided to bring him inside and give him a warm bath since it was in the high 70’s. He was non responsive to his bath- no playing with the hose or even accepting peppermints. I placed a cooler on him to ensure he stayed warm until he was out in the sunshine. I figured after a bath he would perk up- again, I was wrong. At dinner time I went to bring him in and typically I will open up the gait and he will canter into his stall- he slowly walked instead. He wouldn’t eat his feed (he normally whinnies and makes a fuss until he gets his feed and devours it) or his hay…I stayed and watched him for a while and he just slept. I spoke to John, the guy who helps me with Chance and Lucky, and he confirmed that Chance hadn’t been finishing his feed and wasn’t running when he brought him in for dinner.
My concerns grew and I decided to do some research on Excede. That strange thing is I usually do extensive research before changing or administering anything with my animals. But, for some reason I did not do so this time and I wish I had.
According to a number of reputable websites, Excede can cause significant and dangerous side-effects such as; diarrhea, severe acid reflux, blood coming from mouth, loss of appetite, lethargy, muscle and gait stiffness, and more.
The most troubling of everything that I read wasn’t what was posted on the Pfizer (the manufacturer) website but from the countless statements given by horse owners and the studies done by outside companies.
According to drugs.com, “in the PK study, several horses developed clinical signs consistent with foot pain (stiff in the front limbs when turned in tight circles, and increased pulses and heat to the front feet). One horse in the NAXCEL group and one horse in the 6.0 mg/lb (2X) EXCEDE group were euthanized due to laminitis. Clinical signs of foot pain (stiff front limbs and increased heat and pulses in feet) affected more horses, for a longer period of time, in all EXCEDE-treated groups as compared to the NAXCEL-treated group. The study housing (multi-horse pens on concrete slabs) and diet (free choice alfalfa/grass mix and once a day pellets) may have contributed to the development of foot pain. The prevalence and severity of injection site reactions in EXCEDE-treated horses may also have contributed to the development of a stiff gait. A causal relationship between ceftiofur and foot pain could not be definitively determined.”
The research has revealed that Excede should be used with caution and the horse receiving the medication must be monitored. Make sure to weigh the benefits and risks before starting Excede. This drug can be lifesaving for many horses but for others, it can be life-threatening.
Over the last couple weeks the rain has been unrelenting. And with rain comes scratches (Pastern Dermatitis). In a previous entry I spoke about an amazing treatment for scratches that actually worked…however, when it rains like it has recently, once again the scratches got out of control.
A handful of months ago I got a skin scrape on Chance’s hind legs to determine the bacteria that was causing the scratches. Sure enough there were three types of bacteria growing which was why I was having so much difficulty getting them under control.
Below are the results:
As you can see above, the bacteria shows resistance or no interpretation to all but 7 antibiotics. I spoke to my vet and she suggested beginning with Gentamicin and go from there if he does not respond to the medication. Chance has been receiving an injection of 30 mls of Gentamicin in his muscle once a day for about a week now. He obviously does not enjoy this, nor do I for that matter, but his scratches are showing improvements! He is also on the topical cream, Silver Sulfadiazine, once a day.
Fingers crossed that I will get ahead of the scratches and they will go away forever!
The other day I noticed that Chance’s back fetlock a were slightly swollen and he was visably stiffer then normal. I also noticed a golf ball sized lump in the middle of the his chest. It wasn’t super sensitive and looked like a tick bite reaction, except there was no tick and a tiny barely noticeable scratch.
I put a Poltace wrap on his back right leg (which was the leg he had previously injured and received stem cell injections in) and gave him some pain medication. I also started him on Baytril and Ulcerguard as a precaution as previously advised by the vet.
I made an appointment with our vet to come ultrasound his hind right leg and she was to come out in the next two days. I was incredibly anxious to say the least.
The vet arrived and explained that the lump on Chance’s chest was a hematoma from another horse biting him or from him hitting something. Nothing to worry about, it was just the pooling of fluids to lowest point.
I then trotted Chance back and forth as the vet watched. After an exam and the ultrasound, the vet explained that she felt that the swelling was due to Chance’s hip pain and the Pastern dermatitis that we have been treating and we’re finally coming off.
The ultrasound showed a tiny DDFT lesion (vet referred to as a defect that shouldn’t be causing any symptoms). The ultrasound also showed scar tissue that we need to get “stretched out” so that he can gain increased flexibility and work as a protection for Chance’s tendons and legiments. The ultrasound also showed some fluid build up as well. Chance’s Fetlock looks good as do his legiments.
The vet wants Chance to stay on Baytril and Ulcerguard until complete. She also has added a 5 day course of Benadryl and steroids to help with edema of back hind legs.
She also provided me with a shampoo that is milder to clean off scratches and apply swat after cleaning. The vet explained that she didn’t understand why people picked the scabs from the scratches because they’re super deep and pulling the scabs off does more harm than good.
The Vet commented on Chance’s weight gain and how great his skin looks gooded. She wants me to continue working on the scratches and continue doing physical therapy on hills to build up his hind end then get farrier out for back feet.
All and all I feel good about how Chance is doing and feeling. He is still full of energy, eats like he hasn’t eaten in a week, and his eyes and coat are bright. He is not on daily pain medication and is only given it when he is not feeling great. Aside from a few hiccups, Chance is loving life and being spoiled!
4:30am is clipping time! Chance has never been clipped but due to his unrelenting shedding and the allergic skin response, there’s no better time to try.
Chance was awesome! He stood quietly as I clipped him for over an hour and I decided to stop when I noticed he had fallen asleep. I guess not everyone is a night owl.
The other day the vet gave me a way to treat and get rid of my horse’s treatment- resistant, stubborn, and seemingly IMPOSSIBLE to get rid of scratches or Pastern Dermatitis.
She suggested mixing Betadine and Vaseline and applying it to the infected area, then wrapping it with Seren wrap and a standing wrap. Leave it on for 12 hours, remove, clean, and redo if necessary for up to 3 days.
Well, it worked! The scabs just fell off! No more trying to pick off the scabs resulting in the discomfort of my horse or struggling to get him to let me pick at him!
I have been fighting my horse’s scratches for about 15 years- antibiotics, ointments, MTG, baby oil to soften them, Zinc Oxide, wraps, immune boosters, etc- and nothing has worked until now!