Tag Archives: Baytril

Immune Booster Leads to Infection?

For the past 6 weeks, my horse has been receiving Ozonetherapy to aid in his chronic back leg related issues- dermatitis (“scratches”), previous DDFT tendon laceration, a history of Lymphingitis, and the residual scar tissue from his DDFT injury.  Due to his age (27), he lacks proper circulation in his hind end which does not help him fight his pastern dermatitis.  


According to the American Academy of Ozonetherapy, Ozonetherapy is described as;

“Ozonotherapy is the use of medical grade ozone, a highly reactive form of pure oxygen, to create a curative response in the body. The body has the potential to renew and regenerate itself. When it becomes sick it is because this potential has been blocked. The reactive properties of ozone stimulate the body to remove many of these impediments thus allowing the body to do what it does best – heal itself.”

“Ozonotherapy has been and continues to be used in European clinics and hospitals for over fifty years. It was even used here in the United States in a limited capacity in the early part of the 20th century. There are professional medical ozonotherapy societies in over ten countries worldwide. Recently, the International Scientific Committee on Ozonotherapy (ISCO3) was formed to help establish standardized scientific principles for ozonotherapy. The president of the AAO, Frank Shallenberger, MD is a founding member of the ISCO3.”

“Ozonotherapy was introduced into the United States in the early 80’s, and has been increasingly used in recent decades. It has been found useful in various diseases;

  • It activates the immune system in infectious diseases.
  • It improves the cellular utilization of oxygen that reduces ischemia in cardiovascular diseases, and in many of the infirmities of aging.
  • It causes the release of growth factors that stimulate damaged joints and degenerative discs to regenerate.
  • It can dramatically reduce or even eliminate many cases of chronic pain through its action on pain receptors.
  • Published papers have demonstrated its healing effects on interstitial cystitis, chronic hepatitis, herpes infections, dental infections, diabetes, and macular degeneration.”

 

After doing research and speaking to one of my good friends, we determined that Chance’s flare up of Lymphingitis, after almost 3 years of not a single issue, could possibly be caused by his immune system’s response to Ozonetherapy.  Let me explain.

Chance suffers from persistent Pastern dermatitis (“scratches”) since I purchased him in 2000.  I have tried everything- antibiotics, every cream and ointment and spray for scratches, diaper rash ointment, iodine and vaseline mix, Swat, laser treatments, scrubs and shampoos, shaving the area, wrapping the area, light therapy…you name it, I have tried it.  So, when we began Ozonetherapy to help break down the left over scar tissue from his old DDFT injury, I noticed that his scratches were drying up and falling off.  We continued administering the Ozonetherapy once a week for about 6 weeks.  The improvement was dramatic!  

However, one day Chance woke up with severe swelling in his left hind leg and obviously, he had difficulty walking.  He received Prevacox and was stall bound for 24 hours.  The vet was called and she arranged to come out the following day.  The next morning, Chance’s left leg was still huge and he was having trouble putting weight on it.  I did the typical leg treatments- icing, wrapping.  The swelling remained.  I tried to get him out of his stall to cold hose his leg and give him a bath but he would not budge.  He was sweaty and breathing heavily and intermittently shivering.  So, I gave him an alcohol and water sponge bath and continued to ice his back legs.   I sat with him for 4 hours waiting for the vet to arrive.  He had a fever and wasn’t interested in eating and his gut sounds were not as audible.  He was drinking, going to the bathroom, and engaging with me.  I debated giving him Banamine but did not want it to mask anything when the vet did arrive.  

The vet arrived, gave him a shot of Banamine and an antihistamine and confirmed that Chance had a fever of 102 degrees and had Lymphingitis.  There was no visible abrasion, puncture, or lump… I asked the vet to do x-rays to ensure that he did not have a break in his leg.  The x-rays confirmed that there was no break.  The vet suggested a regiment of antibiotics, steroids (I really am against using steroids due to the short-term and long-term side effects but in this case, I would try anything to make sure he was comfortable) , prevacox, and a antacid to protect Chance from stomach related issues from the medications.  It was also advised to continue to cold hose or ice and keep his legs wrapped and Chance stall bound.  

The following day, Chance’s legs were still swollen but his fever had broken.  The vet called to say that the CBC had come back and that his WBC was about 14,00o. She suggested that we stop the steroids and do the antibiotic 2x a day and add in Banamine. I asked her if she could order Baytril (a strong antibiotic that Chance has responded well to in the past) just in case.  And that is what we did.  

Being as Chance had such a strong reaction to whatever it was, I did some thinking, discussing, and researching…first and foremost, why did Chance have such an extreme flare up of Lymphingitis when he was the healthiest he has ever been?  And especially since he had not had a flare up in 3+ years…plus, his scratches were getting better not worse.  The Ozonetherapy boosted his immune system and should provide him with a stronger defense against bacteria, virus’, etc.  So why exactly was he having a flare up?  And that is when it hit me!

In the past when Chance began his regiment of Transfer Factor (an all natural immune booster), he broke out in hives.  The vet had come out and she felt it was due to the Transfer Factor causing his immune system to become “too strong” and so it began fighting without there being anything to fight, thus the hives.  My theory- Chance started the Ozonetherapy and his body began to fight off the scratches by boosting his immune system.  As the treatments continued, his immune system began to attack the scratches tenfold.  This resulted in his Lymphatic system to respond, his WBC to increase, and his body temperature to spike.  Makes sense…but what can I do to ensure this is not going to happen again?  

My friend suggested attacking the antibiotic resistant bacteria by out smarting them…okay, that seems simple enough…we researched the optimal enviroments for the 3 types of bacteria present where Chance’s scratches are (shown in the results of a past skin scape test).  The bacteria – E. Coli, pseudomonas aeruginosa and providencia Rettgeri. The literature stated that PA was commonly found in individuals with diabetes…diabetes…SUGAR!  How much sugar was in Chance’s feed?  I looked and Nutrina Safe Choice Senior feed is low in sugar…so that is not it.  What else can we find out?  The optimal temperature for all three bacteria is around 37 degrees celsius (or 98.6 degrees fahrenheit), with a pH of 7.0, and a wet environment. Okay, so, a pH of 7.0 is a neutral.  Which means if the external enviroment (the hind legs)pH is thrown off, either to an acidic or alkaline pH, the bacteria will not have the optimal enviroment to continue growing and multiplying.  How can I change the pH?  

Vinegar!  An antimicrobial and a 5% acetic acid! And…vinegar is shown to help kill mycobacteria such as drug-resistant tuberculosis and an effective way to clean produce; it is considered the fastest, safest, and more effective than the use of antibacterial soap.  Legend even says that in France during the Black Plague, four thieves were able to rob the homes of those sick with the plague and not become infected.  They were said to have purchased a potion made of garlic soaked in vinegar which protected them.  Variants of the recipe, now called “Four Thieves Vinegar” has continued to be passed down and used for hundreds of years (Hunter, R., 1894).

I went to the store, purchased distilled vinegar and a spray bottle and headed to the farm.  I cleaned his scratches and sprayed the infected areas with vinegar.  I am excited to see whether our hypothesis is correct or not…I will keep you posted!

 


References & Information


Effect of pH on Drug Resistent Bacteriaijs-43-1-174

NIH: Drug Resistant Bacteria

Vinegar

Lymphatic Conditions

Horses Side Vet Guide

What does my horse’s CBC mean?

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Nutrena SC Senior feed ingredience
The American Academy of Ozonetherapy

Hunter, Robert (1894). The Encyclopaedic Dictionary. Toronto: T.J. Ford. ISBN 0-665-85186-3.

 

Fall Fever

Today Chance had swelling of his back right fetlock.  He had a fever around 104 and didn’t eat his feed.  His eyes were dull and he was lethargic.  He wasn’t limping but was walking slower than normal (he usually runs to the paddock or back to the barn).  I decided, due to the Lymphingitis flare up on his back right leg, I would give him a shot of 5 mls (or 5 cc) of Banamine and wrap his leg.  Once the medication set in, I would bring him in to give him a bath (it was 80 degrees today).  So, that is what I did.  By the time he was back at the barn he was covered in sweat.  I cold hosed him and drenched the wrap in cool water and let him roam around the barn.

Thankfully, the vet was able to meet me at her veterinary practice so that I could pick up Baytril and more Banamine.  Since Chance just had Lyme Disease (and had finished his medication less than a week ago), we are not 100% if this is a Lyme reaction or something else.  The plan is to administer 25 cc of Baytril either orally, in his feed, or via IV for 6 days and Banamine 10 mls (or a 1000 lbs) twice a day for 3 days. The vet suggested that I do 5 cc of Banamine if his fever remains between 101-103 degrees and 10 cc if his fever is 103 degrees or above.   During this time I will begin Prevacox- one 1/4 of a tablet once a day.  After 3 days, I will discontinue the Banamine and continue the Prevacox.  If his fevers are not down in two days, I will continue the Baytril but start the doxycycline as it maybe a Lyme disease symptom.

While researching Lyme Disease, I found that many people do two+ months of doxycycline instead of 30 days to ensure the disease has been erraticated completely.  However, since Chance had shown such improvement after 30 days, I decided to not do another month.  Maybe I should have…

However, Chance had similar symptoms when we found a small laceration in the DDFT tendon of his back left hind- swelling, Lymphingitis, fever, lethargy, no appetite, etc.  If he does have an issue with his tendon I will most likely do another round of Stem Cell treatments which proved to be helpful last time.  Thankfully I stored his stem cells in a Stem Cell Bank (via Vet-Stem) and can easily have them shipped.

 

When It Rains, It Pours

The other day I noticed that Chance’s back fetlock a were slightly swollen and he was visably stiffer then normal. I also noticed a golf ball sized lump in the middle of the his chest. It wasn’t super sensitive and looked like a tick bite reaction, except there was no tick and a tiny barely noticeable scratch. 

I put a Poltace wrap on his back right leg (which was the leg he had previously injured and received stem cell injections in) and gave him some pain medication. I also started him on Baytril and Ulcerguard as a precaution as previously advised by the vet.

I made an appointment with our vet to come ultrasound his hind right leg and she was to come out in the next two days. I was incredibly anxious to say the least.  

The vet arrived and explained that the lump on Chance’s chest was a hematoma from another horse biting him or from him hitting something. Nothing to worry about, it was just the pooling of fluids to lowest point. 

I then trotted Chance back and forth as the vet watched. After an exam and the ultrasound, the vet explained that she felt that the swelling was due to Chance’s hip pain and the Pastern dermatitis that we have been treating and we’re finally coming off. 

The ultrasound showed a tiny DDFT lesion (vet referred to as a defect that shouldn’t be causing any symptoms). The ultrasound also showed scar tissue that we need to get “stretched out” so that he can gain increased flexibility and work as a protection for Chance’s tendons and legiments. The ultrasound also showed some fluid build up as well. Chance’s Fetlock looks good as do his legiments.

The vet wants Chance to stay on Baytril and Ulcerguard until complete. She also has added a 5 day course of Benadryl and steroids to help with edema of back hind legs. 

She also provided me with a shampoo that is milder to clean off scratches and apply swat after cleaning. The vet explained that she didn’t understand why people picked the scabs from the scratches because they’re super deep and pulling the scabs off does more harm than good.  

The Vet commented on Chance’s weight gain and how great his skin looks gooded. She wants me to continue working on the scratches and continue doing physical therapy on hills to build up his hind end then get farrier out for back feet. 

All and all I feel good about how Chance is doing and feeling. He is still full of energy, eats like he hasn’t eaten in a week, and his eyes and coat are bright. He is not on daily pain medication and is only given it when he is not feeling great. Aside from a few hiccups, Chance is loving life and being spoiled!

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Update!

After two rounds of EPM treatments, stem cell injections, acupuncture, chiropractic adjustments, testing, antibiotics, ultrasounds, blood work, adding DuraLactin….Here is a video of Chance yesterday!  He has gained a lot of weight back and hopefully, with the addition of the Rice Bran in his feed, he will continue to gain weight!

Stem Cell Injections

We decided to go ahead with the Stem Cell injections through the company Vet-Stem.  Though expensive, they carry virtually zero risk, aside from a site infection, in comparison to the surgery.

Vet4 will gather the cells from his rear and stitch up the incisions made.  From there, if there are enough cells, the culture will be sent to the lab, and in about two days, they are able to be injected into the leg!

UPDATE:

There were enough Stem Cells to inject!  Chance is doing extremely well and is able to come home in a few days!!!

I asked if Vet4 could get Chance supportive back shoes before he left and he said he would.

Time to set up a trailer and get his stall ready in Sperryville!!!!

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DDFT Lesions

Text from Vet4 after ultra sound #3:

“I can see that he has a deep digital flexor tendon lesion and the medial side of the tendon sheath has improve but lateral side is about the same. The DDFT may the cause of all this in the first place and everything else is secondary. We will re ultrasound in 10 days or so just to confirm my findings. If they are correct, it would help to treat that area.”

Conversation with Vet4 :
So far, Chance has received; shock wave therapy, compression therapy and laser therapy.

Chance has a hole in his tendon. Vet4 believes that this is due to an infection/bowed tendon and severe lameness. The ultrasound, done yesterday, shows no change in size of the tendon hole after the previous two rounds of injections.

“Lymphangitis is a symptom rather than a cause and the cause was never treated.” Vet1 continued to treat it like a disorder rather than a symptom!

The swelling and infection have dissipated, as has the severity of the lameness. Though still lame, he is running around in the pasture.
Pain meds were started again due to increased discomfort and soreness.

Vet4 suggests doing one of the following:

1. Stem cell- which can take about two days if sample drawn has enough stem cells. If not, it could take about 4-6 wks to culture. Once injected he can move home. He is to be hand walked for a few days and then can go out as normal. Vet4 will come out in about a month to do another ultrasound and, depending on the size of the hole, may need to do further injections.

2. Surgery to clean out but NOT repair the tendon. This was not discussed in detail.
Payment plans may be an option. I emailed the office for payment options.

Time to make another decision!

100% Turn Around!

Spoke with Vet4 today. He said Chance has made a “100% turn around”. He trotted him today and Chance was putting full weight on both hind feet! Swelling is disappearing as well!

We spoke about further treatments aside from the Baytril.

I asked about potassium penicillin- He is apprehensive to do potassium penicillin due to horses on antibiotics having DNA changing effects. That it is best to stick to the Baytril and do an ultrasound tomorrow (Friday) to view any changes to the masses. He suggests to have Baytril on hand when Chance leaves to begin immediately if swelling occurs again, which he believes will not be the case after this hospitalization.

I asked about Hydraulic acid: He also is hesitant to inject the SS with the Hydraulic acid due to it’s effects on certain bacterial strains- often allowing the bacteria to hide from the antibiotics. He does agree that another round of injections would probably be helpful and will know more after the next ultrasound.

When asked whether scratches can lead to Lymphangitis, thus leading to the infected SS, he said it is hard to tell but certainly possible.

Chance is currently receiving laser therapy and cold compression therapy along with Baytril, pain meds, and supplements.

Vet4 believes that Chance should be able to leave within a week to two weeks depending on progress!

Going, Going…..

GONE!

Chance’s fever is still at bay, the swelling is almost gone, he is sound, eating, and the light has come back into his eyes!!!

I quickly tried to set up a trailer to haul Chance to the hospital where he would begin further diagnostics and treatments.  I would have taken him soon if I felt that he was stable enough to withstand the haul.  But he was too unsteady until now!

It took a few days, there was a trailer and someone to haul him (thanks to Vet3) and we had him on his way to the hospital!  I was there waiting for him to arrive.

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Waiting Games

We began Baytril on 8/16.  The next day Chance came in from pasture with NO fever, NO trouble walking, but also NO appetite- eating a little grain, hay stretcher, peppermints and the swelling worse.

Chance got Compounded Baytril- 2 scoops with feed previous pm. Vet3 advised us to give another dose of Baytril but Chance won’t eat (most likely due to the taste of the Baytril in feed previous night. But Vet3 believes it is due to his pain). So, we gave another dose of Banamine/10 cc (am and pm) and Tridex- 1 packet. Iced 2x/kept in/ wrapped both hind legs with boots.  And the waiting game begins!

Research, Research, Research

Tendon Injury Handbook

After I left the barn, I drove home and went straight to my computer.

What was happening?  What are the masses? Scar tissue?  Nothing was able to be extracted out of them…How can I get rid of them in order to see behind them?

Again, I stayed up until the sun came out the next morning.  I already had two binders full of research and now I had a third.

Research made me believe that C has an infection in the Synovial Tendon Sheath that was being masked by the masses on the outer lining of the SS. The masses could be scar tissue from his MANY past Lymphangitis flare-ups. Perhaps, his immune system was not able to fight last attack and the infection settled in the SS and was walled off.  Thus his CBC & WBC were normal and no fluid was extracted from SS masses due to the large size of the scar tissue.
C has a major hx with his RH and “flare-ups” and lameness. I never realized this until I took the time to study his past records from the first 5 years I owned him.

Symptoms are similar to an infection- what if we proceeded as if it were?
Lack of a positive culture does NOT mean that there is not an infection in the sheath!

Current Symptoms:
1. Swelling decreases after being active
2. Fails to extend fetlock
3. Lame- exasperated by flexion
4. Positioning for fetlock flexion

Septic Synovitis: Cartilage degradation ischemia, Fibrin deposition lead to lameness to pannus form and adhesive form

Entrobacteriacaea
Strep
Staph
Most common is Staph

Treatment: 

Systematic Procaine Penicillin 22000 iU/kg or Sodium Benzyl Penicillin & Gentamicin 6.6 mg/kg for 2-9 days

Then change to oral potentiated sulfonamides 5mg.kg Trimethoprim and 25 mg/kg of Sulphadiazine

Other potassium penicillin w/ Amikacin Cectiofur or Enrofloxacin

IV antibiotics for 7-10 days switch to oral for 2 weeks

Regional limb profusion or placement of impregnated Polymethyylmethacralate or PMMA

I immediately called Vet4 and told him my theory.  He said that it was possible and that we should begin treatment asap.  He was still out of town so I called Vet3 to order Baytril. Vet3 felt my theory was legit and immediately ordered the antibiotic!

The Call

One day I received a call that I needed to come out and see Chance because he wasn’t doing well and, according to Vet1, he needed to be put down.  I quickly canceled my appointments and got on the road.  The 4 hour drive was excruciating…once we finally arrived, my heart broke.

My old guy was skin and bones.  His back right leg was swollen and he wasn’t able to bare weight on it.  His eyes were dull.  He could barely walk, and when he did, he wouldn’t put any weight on the right hind.  There were even times when he would do this “neurologic dance” (coined by the farm’s owner and C’s other mom) where he would lift up his back right leg and hop!

But when he saw me pull up, he whinnied.  He was excited to see me.  He ate the pureed carrots but refused the apple puree (only my mom would make this for him).  He wasn’t ready to die.



I called the vet who said that Chance should be put down to see what his thoughts were.

Me:   What do you think is going on with C?

Vet1: I think he is ready to be put down. 

Me: Because of what?

Vet1: Lymphangitis

Me: Okay, well, what is the cause of the Lymphangitis? Did you run any diagnostics?

Vet1: No

Me:  I would like to manage his pain and run a few tests before making that decision.  (I reviewed the research that I had done and asked where to go from there.) Could it be EPM?

Vet1: “It’s not EPM”

Me: How about Cushings? Or Laminitis? Lymes?

Vet1: Nope. Just old age.

Me: The journals I read said that some of the symptoms…(I was cut off)

Vet1: “I don’t care what journals you read!  It’s a bunch of…”

Me: One was from VA Tech actually…



Well, that was that! Vet1 did not completely lack compassion but he was more “old school” I guess one could say.  He was well respected in the horse world and up until this point, he did the job I needed. But I will say I was disheartened by our conversation.  

I decided to contact the other vets that I had worked with in the past, who also knew Chance, and get second, third, fourth opinions.  

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